Ayton was born in 1998 in Nassau, Bahamas to parents Andrea and Alvin Ayton. He has three brothers and two sisters. Ayton played soccer in his youth but decided to seriously pursue basketball at the age of 12. After showing promise at the Jeff Rodgers Basketball Camp in the Bahamas, he moved to the United States to attend Balboa City School before transferring to Hillcrest Prep. Ayton has played a big role in Hurricane Dorian relief efforts, as the disaster affected his native Bahamas. He pledged $100,000 in September of 2019 and later held a dinner that raised $47.000 for UNICEF's relief fund. Ayton is also involved in the Basketball Without Borders Global Camp, which he attended in 2016 as a participant and in 2019 as a coach. You can follow Ayton on Twitter (@DeandreAyton) and Instagram (@deandreayton).