James Harden sat out for the Brooklyn Nets on Monday night at Portland due to a hyperextended left knee, a game Brooklyn lost 114-108.

Kyrie Irving started in his second game of the season and finished with 22 points. Kevin Durant led all scorers with 28 points and 10 rebounds for the Nets.

Harden had 26 points, 12 assists and seven rebounds in Brooklyn’s 121-119 overtime victory at home over San Antonio on Sunday.

Nets coach Steve Nash said the team was being cautious with Harden in a dense stretch of games and that Harden should be available on Wednesday at Chicago (10 ET, ESPN).

Harden is averaging 22.4 points, 8.1 rebounds and 9.7 assists per game. The late scratch marked the fifth game that Harden has missed this season.

Joining Harden on the Nets’ injury report was former Blazer LaMarcus Aldridge, who has a sore right foot and also missed the game against the Spurs.

Brooklyn was expected to have Kyrie Irving for the second time this season. The seven-time All-Star has refused to get the COVID-19 vaccine and is barred from playing in New York due to the city’s vaccine mandate, but he has resumed playing with the Nets on the road.

Monday’s game was originally scheduled for Dec. 23 but was postponed because of the league’s COVID-19 protocols.

Information from The Associated Press was used in this report.