Denmon committed to attend the University of Missouri on August 20, 2007.
A reserve his freshman and sophomore seasons, Denmon started 33 out of 34 games his junior season. As a junior, Denmon averaged 16.9 points per game while earning All-Big 12 First Team, NABC All-District, and USBWA All-District honors.
On August 3, 2011, Denmon was named to the 2011 USA Basketball Men’s World University Games roster.
As a senior, Denmon 17.7 points per game and 5 rebounds per game, earning second-team Consensus All-American, All-Big 12 First team, and USBWA All-District honors. Denmon was also a finalist for the John R. Wooden Award.
With 107 victories, teammates Denmon, Kim English, and Steve Moore won more games than any senior class in Mizzou basketball history.