| Year | Player | Reason | Replacement (position in balloting) |
| 2007 | Jason Kidd | Sore back | Joe Johnson |
| 2007 | Steve Nash Allen Iverson | Sore shoulder Ankle sprain | Ray Allen (8th in voting for guards) Mehmet Okur (5th in voting for centers) |
| 2007 | Yao Ming* Carlos Boozer | Right knee fracture Left fibular fracture | Carmelo Anthony (3rd in voting for forwards) Josh Howard (8th in voting for forwards) |
| 2006 | Jermaine O'Neal* | Torn groin muscle | Gilbert Arenas (7th in voting for guards) |
| 2003 | Chris Webber | Left ankle sprain | Peja Stojakovic (5th in voting for forwards) |
| 2002 | Shaquille O’Neal* | Arthritis, right big toe | Elton Brand (8th in voting for forwards) |
| 2002 | Vince Carter* | Aggravated left quadriceps tendon | Baron Davis (8th in voting for guards) |
| 2002 | Karl Malone | Personal reasons | Not replaced on roster |
| 2001 | Grant Hill* | Foot injury | Latrell Sprewell (3rd in voting for forwards) |
| 2001 | Alonzo Mourning* | Kidney illness | Dikembe Mutombo (3rd in voting for centers) |
| 2001 | Theo Ratliff | Stress fracture, right wrist | Antonio Davis (6th in voting for centers) |
| 2001 | Shaquille O’Neal* | Strained arch, right foot | Vlade Divac (3rd in voting for centers) |
| 1997 | Alonzo Mourning | Injury week before game | Joe Dumars (5th in voting for guards) |
| 1997 | Patrick Ewing* | Inactive since Jan. 23 | Chris Webber (4th in voting for forwards) |
| 1997 | Charles Barkley* | Injury suffered mid-January | Detlef Schrempf (7th in voting for forwards) |
| 1997 | Shaquille O’Neal | Injury week before game | Kevin Garnett (3rd in voting for forwards) |
| 1997 | Clyde Drexler | Injury week before game | Chris Gatling (not in top 10 for forwards) |
| 1995 | Cedric Ceballos | Injury week before game | Dikembe Mutombo |
| 1994 | Alonzo Mourning | Injury suffered late-December | Horace Grant (not in top 10 for forwards) |
| 1994 | Charles Barkley* | Inactive since Jan. 9 | Gary Payton (8th in voting for guards) |
| 1993 | Chris Mullin | Inactive since mid-January | Selected as a reserve by the coaches despite being injured already, so the coaches selected 8 reserves instead of the usual 7 |
| 1993 | Mitch Richmond | Injury week before game | Terry Porter (5th in voting for guards) |
| 1992 | Larry Bird* | Inactive since Dec. 30 | Michael Adams (3rd in voting for guards) |
| 1992 | Dominique Wilkins | Suffered season ending injury on Jan. 28 | Kevin Willis (not in top 10 for forwards) |
| 1992 | Magic Johnson* | Retired Nov. 7, two days after All-Star ballot was released | Started and played in game; Tim Hardaway was named to team on Jan. 23 when the West starters were announced (2nd leading vote getter among active Western conference guards) |
| 1991 | Larry Bird* | Inactive about a month prior to game | Hersey Hawkins (not in top 10 for guards) |
| 1991 | Isiah Thomas* | Injured prior to announcement of reserves | Eight players named as reserves |
| 1990 | Karl Malone | Injury week before game | Rolando Blackman (not in top 10 for guards) |
* denotes player was selected as a starter


