INDIANAPOLIS, Nov. 5 (Ticker) -- The desperation of Allen Iverson and the Philadelphia 76ers was enough to overcome the relaxation of the Indiana Pacers.

Iverson had 29 points and 12 assists as the 76ers built a big lead and held on for the first win of the season, a 111-109 victory over the previously unbeaten Pacers.

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Chris Webber scored 25 points and made a handful of big shots in the fourth quarter for Philadelphia, which had lost its first three games by an average of 15.3 points but regrouped on the road against one of the NBA's best teams. Iverson played all 48 minutes.

"We gave great effort," Webber said. "That's what it really came down to tonight - execution, timing, players getting involved, a little bit of everything."

"Give Philly credit for how they came in here," Pacers coach Rick Carlisle said. "They deserved to win. I was glad to see us fight back in the fourth quarter, but it's the same old story - you have to play four quarters to win."

After winning a pair of games in Florida -- including a convincing victory at Miami -- Indiana had its home opener spoiled by a slow start that was too much for a furious finish to overcome.

"We waited too late to play," Pacers point guard Jamaal Tinsley said. "Can't wait until the fourth quarter and hope to catch up. We didn't play like we wanted to win tonight."

The Pacers nearly erased a 20-point deficit over the final 15 minutes, closing to 108-106 on a free throw by Ron Artest with 54 seconds remaining. They had a chance to tie the game, but Iverson and Steven Hunter jammed a pick-and-roll, forcing Jermaine O'Neal to settle for an 18-footer that he missed.

"We were looking for that shot," O'Neal said. "I was a little disappointed that I didn't up-fake him and go the the basket. I could have gotten a shorter shot."

Kyle Korver split a pair of foul shots with 18 seconds left, giving Indiana one more chance. But Stephen Jackson and Jamaal Tinsley missed 3-pointers, and Webber sealed it with two free throws.

Webber made a jumper and hook shot to keep the lead at seven points and another jumper that made it 108-102 at the 1:45 mark. Jackson answered with a 3-pointer before Artest's free throw.

Korver ended his shooting slump with three 3-pointers, 15 points and nine assists. Andre Iguodala scored 14 points and Hunter added 13 and five blocks for the Sixers, who shot 55 percent (41-of-74) from the field.

"We had a good talk this afternoon and coach (Maurice Cheeks) challenged us," Korver said. "He didn't yell, he didn't curse or anything like that ... he just told us how it was. I think he said some things we needed to hear. After how we played the last three games, he just laid it on the line."

O'Neal had 23 points and 15 rebounds, Tinsley scored 21 points and Jackson added 20 for the Pacers, who shot 51 percent (40-of-79) but committed 21 turnovers in their fifth straight loss to the Sixers.

"I wouldn't say we were relaxed. It was a multitude of things," O'Neal said. "We just started too late. If we would have gotten ran out of here, I would be concerned."

"They were due to hit some shots; they were 0-3," Jackson said. "Obviously, our defense and our intensity wasn't what we wanted it to be tonight."

Reserve Kevin Ollie scored all seven of his points in the second quarter, when Philadelphia led by 13 points before settling for a 61-52 halftime lead.

Iverson scored 14 points in the third period, including 10 in a four-minute stretch that pushed the advantage to 86-66 with 4:14 left. Carlisle responded by putting his starters back in the game and made just one substitution until the final seconds.