MIAMI, April 10 (Ticker) -- With Shaquille O'Neal on the sidelines and Dwyane Wade ineffective, the Miami Heat's longest home winning streak came to an end.

O'Neal missed his third straight game because of a stomach virus and Wade fouled out with just five points as Detroit ended Miami's franchise-record 18-game win streak, 80-72.

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The Heat's last home loss was to Indiana in overtime Jan. 21.

"This team was not really built to play without Shaq and without Dwyane," Miami coach Stan Van Gundy said. "Dwyane played 21 minutes and had a bad night on top of that. That was obviously a huge factor."

The 18-game winning streak was the longest single-season streak in the NBA since the Sacramento Kings also won 18 in a row from Dec. 4, 2001-Feb. 14, 2002.

Richard Hamilton scored 17 points and Tayshaun Prince added 16 for the Pistons, who won their sixth straight game.

"You have the most talented player in the game of basketball (O'Neal) not out there, so he definitely makes them a different team," Hamilton said.

O'Neal's replacement, Alonzo Mourning, started for the Heat for the first time since April 2002. He was strong on the defensive end, grabbing 14 rebounds and blocking five shots, but struggled offensively, making just 3-of-12 shots and 4-of-8 free throws.

"His defense and his rebounding is something we can use," Van Gundy said. "He also has to be able to convert around the basket. We are not asking him to do too much offensively, but he has got to be able to get it in the paint and finish."

"It was a loss," Mourning said. "I didn't do enough; we didn't do enough. ... When you're shorthanded with your stars out, everyone has to step up. ... I want my play on the court to be consistent enough so we win. I had a kidney transplant and I'm doing well. I'm still capable of playing this game at a high level.

Wade shot just 1-of-6 from the field. The All-Star guard was held to single digits in just one other game this season, spraining his ankle and going scoreless in 18 minutes vs. Washington on Dec. 13.

"We played him with a lot of different people," Detroit guard Chauncey Billups said. "On the other end, we tried to go at him and make him play some defense and wear him down a little bit, so he can't run free on the offensive end. He never really played with a really good flow because of foul trouble."

Wade had 31 points, 10 assists and 10 rebounds the last time the teams met in Detroit on Dec. 30.

Despite trailing 42-30 at halftime and 56-36 midway through the third period, the Heat did not go down without a fight.

Behind 11 fourth-quarter points from Eddie Jones and a 3-pointer by Damon Jones with 70 seconds left, Miami cut the deficit to 74-70. But Hamilton hit three free throws and Billups added two more from the stripe in the last 42 seconds to seal the win.

"We didn't move the ball around like we wanted to move it (in the first half)," Eddie Jones said. "We were forcing up shots that we do not normally make. ... In the second half, we moved a lot better and played better defense."

In a game dominated by defense, Detroit shot 38 percent (29-of-77) but held Miami to just 35 percent (27-of-78).

Miami and Detroit are the top two seeds in the Eastern Conference and favored to face each other in the conference finals.

"I don't care who it is. It doesn't matter," Detroit's Rasheed Wallace said. "We match up with anybody. It doesn't matter if it is the Heat, the Celtics. It doesn't matter who we play -- we'll be ready."