Wade, who played just 26 minutes, scored 21 of his 29 points in the first half as the Miami Heat opened a huge lead and rolled to a 110-71 triumph over the Bucks.
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Bucks-Heat: 300k 
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But it was Wade, not O'Neal, who Miami went to early and often.
"If we needed, he probably could have had 40," Heat forward Udonis Haslem said of Wade.
"If the coaches left him (Wade) in, he would have scored 50," O'Neal added. "He told me he wanted to score 50."
Wade, who finished 10-of-12 from the field, scored 14 points to help Miami open a 29-22 lead after one quarter and added another seven in the second period as the Heat pushed their advantage to 60-37 at the break.
"Dwyane was fabulous in the first half," Miami coach Stan Van Gundy said. "We went to him a bit more early in the game. I wanted to give him a few more looks tonight, and he was making great plays, so it was easy to keep going back to him."
Van Gundy said the decision to go to Wade was a conscious one based upon what he perceived as a slow start against New Jersey on Saturday.
"We wanted to come out and not give Milwaukee any life," Wade said. "Myself, I came out and got a couple of easy baskets that got me going, that got me into the flow of the game. ... The last two or three games I felt like I wasn't aggressive coming out and I wanted to change that.
"I felt real good tonight. I felt in a zone for a while, like I could get to the basket whenever I wanted."
Miami, which has only lost once in regulation in the last 19 games, notched its largest margin of victory over the Bucks in franchise history.
"Guys seemed lost out there at times," Bucks coach Terry Porter said. "I do not know if they were intimidated or what. We just were not in it tonight."
The Heat, who led by as many as 40 points, shot 61 percent (23-of-38) in the first half and 55 percent (41-of-74) overall en route to sweeping the Bucks this season.
"This is the type of game we're supposed to win," O'Neal said.
Milwaukee, which had dropped the first three meetings with Miami by a combined 14 points, connected on just 32 percent (12-of-38) after two quarters and finished at the same rate (25-of-78).
"Maybe in the first quarter we showed some fight, but after then that was it," Milwaukee's Toni Kukoc said.
Michael Redd scored 14 points to pace the Bucks, who have lost six of their last eight games.
"You can rank this as one of our worst outings," Bucks forward Desmond Mason said. "I just think that tonight we didn't come out prepared to play basketball. Like coach said, 'That team's good, but they're not that good.' They're not good enough to beat us by 40 points."
Miami, which improved to 33 games over .500 (49-16) and inched closer to clinching the first playoff berth in the Eastern Conference, would beg to differ.
"We're playing with a lot of confidence right now," Wade said. "We feel like no one can beat us."