MIAMI, Dec. 17 (Ticker) -- Dwyane Wade and Shaquille O'Neal strengthened the Miami Heat's hold on the Eastern Conference.

Wade scored 25 points and O'Neal added 20 and a season-high seven assists as the Heat began a three-game homestand with their seventh straight win, a 107-100 victory over the Denver Nuggets.

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The Heat (18-7) moved three games ahead of Cleveland for the best record in the East and have home games vs. Orlando and Boston before heading out west to face Sacramento and the Los Angeles Lakers.

It was a reversal of the first meeting between the clubs on December 4, a 104-95 home victory by Denver in which it held a 54-34 advantage in points in the paint. O'Neal dominated inside with 9-of-14 shooting and passed out of double-teams to set up easy shots for his teammates.

O'Neal added 11 rebounds and three blocks as Miami outscored Denver, 58-40, in the paint.

Coming off Wednesday's win against Washington in which he had 29 points and nine assists, Wade made 9-of-17 shots. His pull-up jumper from the left corner with 43 seconds left stopped a 12-1 run by the Nuggets and gave the Heat a 105-97 lead.

Denver lost more than a game as star forward Carmelo Anthony had to be helped from the court after spraining his left ankle on a drive with just over four minutes left in the third period. X-rays were negative, but Anthony - who scored 14 points to end his run of 20-point games at seven - is questionable for Saturday's game at Orlando.

Andre Miller had 24 points, seven assists and six steals and Kenyon Martin added 21 and 10 rebounds for the Nuggets, who fell to 3-3 on their seven-game road trip.

After Byron Russell hit a 3-pointer to cut the deficit to 90-80, Christian Laettner sank two free throws and Wade and Laettner each hit jumpers to push the lead to 96-80 with just over six minutes left. The Nuggets used a 12-1 run capped by Miller's three-point play to close to 103-97 with 63 seconds remaining before Wade hit his tough jumper.

Miami shot 57 percent in the first half and got 12 of its 32 points in the paint from O'Neal to open a 57-46 lead. Wade scored eight points and O'Neal added seven in the third period, stretching the advantage to 86-72.