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Manu Ginobili poured in 13 of his game-high 27 points in the fourth quarter, including six free throws in the final 24 seconds, to keep the charging Cavs at bay. Cleveland had scored the first 11 points of the period, but needed Damon Jones' 3-pointer at the buzzer to produce the final one-point margin.
Tony Parker finished with 24 points to become the first European-born player to earn the NBA Finals MVP Award. Parker averaged 24.5 points on 57 percent shooting and five rebounds for the series.
Tim Duncan, who had been named MVP in each of the previous three championship runs, tallied 12 points and 15 rebounds, and averaged 18.3, 11.5 and 2.3 blocks over the four-game set.
LeBron James finished his first Finals experience on a positive note, scoring 13 of his 24 points in the Cavaliers' strong fourth quarter to go along with six rebounds and 10 assists.
With title No. 4, the Spurs join the Celtics (16), Lakers (14) and Bulls (six) as the only franchises with that many. Veteran Robert Horry picked up his seventh ring, the most for any non-Celtic.
Spurs-Cavs: Finals Blog
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Playoff Passions: LeBron James | Tim Duncan
How they got here, Spurs
Conference Finals: Spurs 4, Jazz 1
Conference Semifinals: Spurs 4, Suns 2
First Round: Spurs 4, Nuggets 1
How they got here, Cavaliers
Conference Finals: Cavaliers 4, Pistons 2
Conference Semifinals: Cavaliers 4, Nets 2
First Round: Cavaliers 4, Wizards 0